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2nd Annual Summit on Cell Therapy, Tissue Science and Regenerative Medicine, will be organized around the theme “Regenerative Medicine Research: Showcasing the very real potential with recent results and outcomes”
Regenerative Medicine 2018 America is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Regenerative Medicine 2018 America
Submit your abstract to any of the mentioned tracks.
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The cell therapy branch of the regenerative medicine field has always been innovative in developing new models of delivery with the goal of improving many diseases. Cell therapy is, in effect, transplantation of human or animal cells to replace or repair damaged tissue and/or cells. During the procedure either whole fetal xenogenic cells or cell extracts from human tissue are injected into the patient. The latter method is known as autologous cell therapy if the cells injected are extracted from and transplanted back into the same patient. Several different types of cells can be administered simultaneously. In addition to blood transfusion cell therapy in the form of bone marrow transplant has been conducted for decades which are utilized for the treatment of several types of blood disorders including anemia, leukemia, lymphoma and rare immunodeficiency diseases. Claims have been made by the proponents of cell therapy that it has been used successfully to treat various other diseases too. However, we need to cross many hurdles when it comes to connecting modern cell therapies with the established drug development and sales methodologies.
- Track 1-1Regeneration of Spinal Nerve Cells
- Track 1-2Extracellular Vesicles as the Next Generation Cell Therapy
- Track 1-3Expanding the Cell Types for Administration
- Track 1-4Cell Signaling Pathways and Technology
- Track 1-5Cell based assays
- Track 1-6Cell Differentiation and Cell Fate
- Track 1-7Cell Therapy Products and Methods of Delivery
- Track 1-8Latest Research and Review
Regenerative Medicine refers to a group of biomedical approaches to research and clinical applications which is aimed at replacing or "regenerating" human cells, tissues or organs to restore or establish normal functions which were damaged due to diseases. The field of Regenerative medicine has attracted much attention as it holds the promise of regenerating damaged tissues and organs in the body by replacing damaged tissue or by stimulating the body's own repair mechanisms to heal damaged tissues or organs. It also may enable scientists to grow tissues and organs in the laboratory and safely implant them within the body. Regenerative solutions thus can be a revolutionary step in the field of healthcare.
- Track 2-1Regenerative Medicine Processing
- Track 2-23D printing
- Track 2-3Cell-free regenerative medicine
- Track 2-4Autologous Umbilical Cord Blood (UCB) Cells
- Track 2-5Diabetic Wound Healing
- Track 2-6Novel Cell Sources for Regenerative Medicine
- Track 2-7Organ Transplantation Research
- Track 2-8Updates in Molecular Mechanisms of Regeneration
- Track 2-9Cell Tracking and Imaging of Regeneration
- Track 2-10Advanced Developments in Artificial Organ System
- Track 2-11Success Rate Analysis
Stem cells are the fundamental units for achieving regenerative therapies thus these cells are gaining research and experimental focus for therapeutic screening as well as other interventions. The two most useful characteristics of a stem cell are perpetual self-renewal and the ability to differentiate into a specialized adult cell type. One of the most celebrated successes witnessed in use of stem cells in the field of regenerative medicine is the clinical implementation of bone marrow transplantation for regeneration of the blood-forming system.
- Track 3-1Stem Cell Niche in Regenerative Medicine
- Track 3-2Stem Cell Therapy
- Track 3-3Adipose-derived Stem Cells for Regenerative Medicine
- Track 3-4Adult Stem Cell Sources and Stem Cell Differentiation
- Track 3-5Stem Cell Biology
- Track 3-6Stem Cell Embryology
- Track 3-7Epigenetics
- Track 3-8Induced Pluripotent Stem Cells
- Track 3-9Stem Cell Applications in Treating Degenerative Conditions
Mesenchymal stromal cells have emerged as powerful tool for regenerative medicine field. Mesenchymal stem cells (MSCs) are a population of multipotent progenitor cells residing in bone marrow, fat, and some other tissues and can be isolated from various adult and fetal tissues.
Stem cell transplantation is a procedure in which diseased bone marrow (the spongy, fatty tissue found inside larger bones) is destroyed with chemotherapy and/or radiation therapy and then replaced with highly specialized stem cells that develop into healthy bone marrow. It is most often recommended as a treatment option for people with leukemia, multiple myeloma, and some types of lymphoma. It may also be used to treat some genetic diseases that involve the blood. Although this procedure used to be referred to as a bone marrow transplant, today it is more commonly called a stem cell transplant because it is stem cells in the blood that are typically being transplanted, not the actual bone marrow tissue.
- Track 6-1Cord Blood Stem Cell Transplant
- Track 6-2Epithelial Transplantation
- Track 6-3Immunoisolation of Cell Transplantations
- Track 6-4Immunomodulatory Challenges
- Track 6-5Advances in Stem Cell Transplantation
Tissue engineering is widely used in the biomedical sector for regeneration and repair of diseased or trauma tissues. Tissue engineering addresses tissue and organ failure by implanting natural, synthetic, or semisynthetic tissue and organ mimics that are fully functional from the start or that grow into the required functionality. The field initially focused on skin equivalents for treating burns, but an increasing number of tissue types are now being engineered, as well as biomaterials and scaffolds are being used as delivery systems successfully. A variety of approaches are used to coax differentiated or undifferentiated cells, such as stem cells, into the desired cell type.
- Track 7-1Histopathology
- Track 7-2In-situ Tissue Repair And Regeneration
- Track 7-3Bone Tissue Engineering
- Track 7-4Vascular Tissue Engineering and Regeneration
- Track 7-5Craniofacial Tissue Engineering
- Track 7-6Soft-tissue Regeneration
Scaffolds are one of the three most important elements constituting the basic concept of regenerative medicine, and are included in the core technology of regenerative medicine. Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by combining cells from the body with highly porous scaffold biomaterials, which act as templates for tissue regeneration, to guide the growth of new tissue. Scaffolds has a prominent role in tissue regeneration designs, fabrication, 3D models, surface ligands and molecular architecture, nanoparticle-cell interactions. Porous form of the scaffolds are used in the field for regenerating different tissues and organs in the body.
- Track 8-1Scaffold Cell Survival
- Track 8-2Impact of Scaffold on Organ Function
- Track 8-3Hydrogels
- Track 8-4Standardizing the Scaffold Success
- Track 8-5Scaffold Designs and Models
- Track 8-63D Polymer Scaffolds
- Track 8-7Scaffolds in Tissue Reconstruction
Gene therapy uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient’s cells instead of using drugs or surgery. Several approaches to gene therapy are currently being tested by the researchers including: Replacing a mutated gene that causes disease with a healthy copy of the gene; Inactivating or “knocking out” a mutated gene that is functioning improperly; Introducing a new gene into the body to help fight a disease. Although gene therapy is a promising treatment option for a number of diseases (including inherited disorders, some types of cancer, and certain viral infections), the technique remains risky and is still under study to make sure that it will be safe and effective. Gene therapy is currently only being tested for diseases that have no other cures.
- Track 10-1Combined Gene and Cell Therapy Approach
- Track 10-2Risks and Benefits
Researchers are developing animal models to study various aspects of regenerative medicine such as stem cell repopulation, recellularization, cellular mechanisms underlying limb and spinal cord regeneration etc.
- Track 11-1Preclinical Modeling
- Track 11-2Animal Regeneration Studies
- Track 11-3Cellular Source of Regeneration in Animal Models
- Track 11-4Use of Stem/Progenitor Cells to Replace Missing Tissues
- Track 11-5Regenerative Pharmacology
Regenerative medicine attempts to augment the natural healing process to heal or even “grow back” the damaged tissue viz. muscle, tendon, ligament or cartilage etc. Surgical and non-surgical procedures are performed which are designed specifically to heal and “Regenerate” damaged tissues.
Regenerative rehabilitation combines the principles and approaches from rehabilitation and regenerative medicine for developing innovative and effective methods to promote the restoration of function through tissue regeneration and repair. Regenerative medicine and rehabilitation together can contribute in several ways in patient treatment and care plans.
People with reconstructive needs due to aging, burn injuries, cancer, complex wounds, birth anomalies and other trauma injuries have very limited effective treatment options. Researcher and plastic surgeons are creating regenerative medicine therapies with the goal of both healing the damaged tissue as well as forming new tissue.
- Track 13-1Facial Reanimation
- Track 13-2Applications of Rejuvenation
- Track 13-3Reverse Cellular Aging
Regenerative Medicine is growing and maturing steadily; however, there are many challenges that lie ahead. These include best cell source, most appropriate biomaterials, and reliable ways of expanding the cells and growing them in a three-dimensional environment (stem cell bioprocessing).
- Track 14-1Stem Cell Bioprocessing
- Track 14-2Artificial Vascular Graft Material
- Track 14-3Cell Products Manufacturing and Automatization
- Track 14-4Bio- and Nanomaterials for Regeneration
- Track 14-5Biodegradable Synthetic Polymer
Cell therapies with short shelf-life due to a “fresh” final product (as the product is not designed for a long-term storage) are perfectly acceptable for proof of concept of the cell therapy. But when it enters late-stage development and then commercial production, different constraints arise. Thus a cryopreserved final product becomes a necessity when considering the possibility of a late-stage clinical or commercial product with potentially thousands of doses a year that are needed to be shipped to different hospitals all over a continent or the world.
Clinical trials are research studies carried out with human subjects to evaluate the effects of health-related interventions on health-related biomedical or behavioral outcomes.
Translational research involves future clinical application of the ongoing regenerative medicine and cell therapy studies.
- Track 17-1Regenerative Medicine in Autoimmune Disorders
- Track 17-2Regenerative Medicine in Bone & Cartilage Disorders
- Track 17-3Regenerative Medicine in Cardiac & Vascular Disorders
- Track 17-4Regenerative Medicine in Liver, Lung & Kidney Diseases
- Track 17-5Regenerative Medicine in Dentistry
- Track 17-6Regeneration in Cancer
- Track 17-7Cell Therapy and Regenerative Medicine in Neurological Disorders
- Track 17-8Translational medicine approaches in drug discovery & development
- Track 17-9Bone Metastasis and Regenerative Medicine
- Track 18-1Nanotechnology for Mesenchymal Stem Cell Therapies
- Track 18-2Nanotechnology in Stem Cell Research
- Track 18-3Nanofibers and Nanomedicine in regenerative medicine
Cell therapies, stem cell therapies and regenerative medicine have faced much criticism from scientists, researchers, bioethicists. Much has been talked about the field but very small is done for resolving these issues.
- Track 19-1Unproven Treatments with No Medical Benefits
- Track 19-2Poorly Defined Preparations
- Track 19-3Ethical, Legal and Political Aspects
- Track 19-4Toxicity Assessment and Management
- Track 19-5Efficacy, Safety and Regulatory Aspects
- Track 19-6Possibility of Tumorigenicity
- Track 19-7Funding Challenges
North America has become the global leader in cell therapy market with 50 percent share in the global market as heavy investments are being made for the development and commercialization of cell therapy products. The regenerative medicine market in Asia-Pacific is growing at a faster rate as a result of the intensified Research and Development activity in Japan and South Korea. Governments of some countries like Canada, Japan, and the United States are creating programs, establishing centers of excellence, manufacturing infrastructure and research networks to facilitate the rapid and profitable commercialization of these products in order to reduce the cost of care for aging population. However, the market is hindered to some extent as viable manufacturing infrastructure that supports the mass production of quality regenerative medicine products is still lacking. Therefore, large-scale manufacturing units are needed for autologous cell therapy and combination therapy products to meet the growing market demand.
- Track 20-1Translation and Commercialization
- Track 20-2Currently Available Products in the Market
- Track 20-3Funding Challenges